A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). BUT, this is the first I have heard of the potential risk of lung cancer in those who take Synthyroid. Now, I will bring it to the attention of my Endocrinologist. I cried with joy when I found out there was something really wrong with me. I think part of sharing information here on Inspire is the discussions about the articles we share. As I am the caregiver for my dad who has Stage IV lung Cancer, I hope more research can be done on this topic soon. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer As a never smoker I truly wish I smoked so I could just say that's why I got this. Compared to patients without hypothyroidism, those with a high TSH level before hospitalization stayed in the hospital 1.2 days longer and had a 49% higher risk of 30-day readmission and a 43% . rocket fuel, pesticides, fluoride, which induce low thyroid function. I am going to go for a walk with my dog :)). Maybe because they "treat" only with T4 and not T3? It's usually based on the results of blood tests. Levothyroxine is a widely prescribed medication for the treatment of an underactive thyroid. But what can be done for patients who are at low The authors of the study pointed out that levothyroxine (T4) treatment can lead to medication-induced (iatrogenic) thyroid over-activity (hyperthyroidism) and oxidative stress that can lead to a significant patient discomfort. The authors did not study whether individuals who took Synthroid actually developed lung cancer later in life. Endocrinology 1985, 117:12011208. A couple of caveats to note in this study: The authors found a statistical correlation between the increase in sales of the thyroid medicine Synthroid, and an increase in lung cancer in Italy. Iodine - and the lack of it - is implicated in breast cancer, after all. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional. Correlation is NOT causation. Copyright 2008-2023 GreenMedInfo.com, Journal Articles copyright of original owners, MeSH copyright NLM. 1 The number of individuals with thyroid disorders is expected to continue to grow, having reached approximately 750 million globally in 2012. Acta Endocrinol 1988, 118:460464. In discussing their findings, the authors noted that they could not exclude the possibility that the condition of hypothyroidism could favor the development of lung cancer. Correlation is not causation. I bet in the previous discussion, if there was one, we would have concluded it was likely that it was because people are generally not put on enough levothyroxine. Hypothyroidism reduces respiratory drive and can cause obstructive sleep apnea or pleural effusion, while hyperthyroidism increases respiratory drive and can cause dyspnea on exertion. Monaldi Arch Chest Dis 2003, 59:140145. Non-ASPS articles which could be relevant. Cancer-related fatigue (CRF) is common in lung cancer survivors and can occur at any point in the care continuum. Factors found to be associated with mortality were age, senile dementia, congestive heart failure, chronic renal failure, and a history of cerebrovascular disease. If people do not wish to find out all they can about their disease that is fine too. Endocrinology 2008, 149:22412250. It was the therapist that I went to that referred me to a specialist who ran the correct tests. They then correlated drug sales with cancers, eliminating the contribution of age and smoking for lung cancer risk. I'm not saying that there Is no link between Synthroid and lung cancer. PMID: 23539727, [16] Alan R Gaby. Log In. But I for one, do appreciate anything that other members forward about potential links, causes, aids to healing, whatever you can them. I have been reading Izabella Wentz. [3] Faber J, Poulsen S, Iversen P, Kirkegaard C: Thyroid hormone turnover in patients with small cell carcinoma of the lung. Very interesting article, thank you for sharing. The estimated 2.3 million new cases indicate that 1 in every 8 cancers diagnosed in . [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Marketed as superior to traditional glandular forms extracted from pigs (whose endocrine glands are far more bioidentical than any other animal we know of) due to the dose-to-dose standardization of the so-called 'active ingredient' T4 versus the natural variations in hormone concentrations found in the 'real thing,' which incidentally contains a wide range of additional hormones including T1, T2, T3, all of which are vitally important. [5]Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5 deiodinase in lung cancer with peripheral lung tissues. Importance: Whether radioactive iodine (RAI) therapy for hyperthyroidism can increase cancer risk remains a controversial issue in medicine and public health. Brit Med J 1978, 1:210212. hyperthyroidism. [7] They also elaborate on a mechanism of T4-induced lung tissue toxicity: "[I]n rats lung the deiodination of LT4 is the lowest compared to all the other tissues. Here members can share stories, find important information and learn from the experiences of others like themselves. Ultimately, this Italian study brings further attention to one of a wide range of unintended, adverse health effects associated with the overdiagnosis and subsequent overtreatment of hypothyroidism, and the underlying failure of the conventional, largely drug-based paradigm to comprehend the causes and real solutions of disease and human suffering. That's all. I will respond more later onBut I will briefly say I was on Synthyroid from 1993 to 2011. Also, what is oxidised stress??? This discussion has been closed to comments. Physician/Author on Facebook. Heart problems. Not what people like me are saying. Comp Biochem Physiol C Toxicol Pharmacol 2002, 133:475481. I very much appreciate the information you shared. Asesora y Consultora Web3 para empresas. undefined will no longer be visible to you including posts, replies, and photos. [11] Wan J, Chai H, Yu Z, Ge W, Kang N, Xia W, Che Y: H1F-1 on angiogenic potential in human small cell carcinoma. [15] [16]There is also the more logical option of support the bodys thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. Nope. [14] K A Woeber. If You Don't Want Older Bones, Don't Be Low In Vit Background Mortality Rate for Vaccines, or Pseudo Everything You Ever Wanted to Know About Black Seeds. I have so much to say about this I could write a book. 2002 Feb ;25(2):106-9. They found no significant correlation between T4 sales and breast, colorectal and gastriccancers, but did find a significant correlation for lung cancer (p < 0.05) corrected forsmoking and age. El almacenamiento o acceso tcnico es necesario para crear perfiles de usuario para enviar publicidad, o para rastrear al usuario en una web o en varias web con fines de marketing similares. I invite those interested to read it and perhaps we can have a discussion on this study. [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.'. [13] Hollowell JG, Staehling NW, Flanders WD, et al. Medical Authoritys System Kills: FDA-Approved Dru Cognitive Impairment, Memory Loss and Alzheimer's Soy Lecithin: How It Negatively Affects Your Healt Cannabis Oil Cures Cancer -Lincoln Horsley's Story New Information Dissolves Illusions About Vaccines Grounding Helps Thin Dangerously Thick Blood and F Tart Cherries Relieve Osteoarthritis Pain, Lieberman's Massive Connections To Big Pharma, Utopian 'Harvest Your Own' Groceries Coming Up. According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called subclinical hypothyroidism only detected via blood work. [9] Otto T, Fandrey J: Thyroid hormone induces hypoxia-inducible factor 1 gene expression through thyroid hormone receptor /retinoid x receptor -dependent activation of hepatic leukemia factor. For more information, please see our Endocrinol. Sayer Ji is the founder ofGreenmedinfo.com, a reviewer at theInternational Journal of Human Nutrition and Functional Medicine,Co-founder and CEO of Systome Biomed, Vice Chairman of the Board of theNational Health Federation, and SteeringCommittee Memberof the Global Non-GMO Foundation. As a person with Graves Disease, I underwent 6 cycles of radio-ablation using i 131 to 'fry' my thyroid gland as surgery was deemed too risky due to the vascularity and size of my gland. The Remarkable Heart-Friendy Properties of Avocados. radioactive treatments. By accepting all cookies, you agree to our use of cookies to deliver and maintain our services and site, improve the quality of Reddit, personalize Reddit content and advertising, and measure the effectiveness of advertising. Nah, I would give this much credence. Non-small cell lung cancer is the most common type of lung cancer, accounting for about 81% of all cases. Curr Opin Endocrinol Diabetes Obes 2010, 17:432436. J Endocrinol Invest. I discovered this article published in Wakeup World. The very concept of "marketing" is at odds with the real nature of these materials, which has to do with the protection and expansion of our nature and potential. LifeGivingStore.comRed Light Therapy - Hydrogen Water Generators - Cascara Sagrada - Vitamins, Minerals & Amino Acid Supplements - Cocoa Products - Handcrafted Soaps - Grass Fed Organs & Glandulars - Nano Soma. Whereas a patient who had suboptimal thyroid function, but did not have noticeable symptoms, is suddenly given pharmacological doses of synthetic T4 and suddenly experiences the wide range of acute, adverse health effects associated with a now hyperactive and/or increasingly disrupted thyroid, as a result. The authors also cite animal experimental research which has shown that T4 increases the oxidative stress[6] and spontaneous pulmonary metastases in mice. [8] This means that the amount of LT4 reaching the lungs following an external supplementation cannot to be transformed into LT3 as in the other tissues, and make lungs very vulnerable to possible toxic effects of LT4. I have so many women friends and family members who have recently been diagnosed with hypothyroidism and their doctors put them all on Synthyroid. If I can help someone, fine. Join the forum, it's quick and easy . Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the low thyroid, why call chemical poisoning hypothyroidism? Overtreatment, of course, is the hallmark danger of overdiagnosis. [5] Wawrzynska L, Sakowicz A, Rudzinski P, Langfort R, Kurzyna M: The conversion to triiodothyronine in the lung: comparison of activity of type I iodotironine 5' deiodinase in lung cancer with peripheral lung tissues. See more of Keri Topouzian, D.O. Modern Medicine, Part I: How Healing Illness Becam Is your body getting too acidic? Thank you for posting it, I agree we all need as much knowledge as we can get! I have sent the link that I read today. The omnipresent environmental contaminant perchlorate, an ingredient in jet fuel, is also a primary cause of hypothyroidism, but is almost never tested for by the conventional endocrinologists in their patient evaluations. [13] Hollowell JG, Staehling NW, Flanders WD. Metab.87 (2): 48999. There are many links attached. But what can be done for patients who are at low [2], The observation that patients with small cell carcinoma of the lung often present symptoms suggestive of hyperthyroidism (i.e. [10] Hofer T, Desbaillets I, Hpfl G, Wenger RH, Gassmann M: Characterization of HIFD-1 alpha overexpressing Hela cells and implication for gene therapy. Share your experience, learn from others. Article published in Wakeup-World.Com. The authors expanded on their findings further: "However, the impression we get from our experience in epidemiological studies monitoring[12] is that this drug should be prescribed more cautiously. So I will leave it as a simple thank you for passing this along. This article is copyrighted by GreenMedInfo LLC, 2013, Some features are currently member only features. Based just on this article, I think the study's conclusion that Synthroid may cause an increase in lung cancer risk is premature. Levothyroxine therapy and serum free thyroxine and free triiodothyronine concentrations. 'A new Italian study published in the journal Reproductive Biology and Endocrinology titled, "Levothyroxine and lung cancer in females: the importance of oxidative stress," has raised a concerning possibility: levothyroxine (T4), one of the world's most commonly prescribed forms of hormone replacement, may be raising the risk of lung cancer in millions of men and women being treated for low thyroid function (hypothyroidism). Thyroid dysfunction after immune checkpoint inhibitor treatment in a single-center Chinese cohort: a retrospective study It is very tormenting (for me anyhow) to not know why I got this disease. She wrote about a product called Thyrtophin PMG. El almacenamiento o acceso tcnico es necesario para la finalidad legtima de almacenar preferencias no solicitadas por el abonado o usuario. Desiccated thyroid extract compared with levothyroxine in the treatment of hypothyroidism: a randomized, double-blind, crossover study. bear in the big blue house characters; colne times obituaries this week Menu Toggle. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism. Dr Childs guesses that patients on levothyroxine monotherapy may be more prone to cancer because they might be under-treated. Or, if fluoride, mercury, or any number of xenobiotic chemicals in the environment requiring selenium-dependent glutathione-mediated detoxification is causing the "low thyroid," why call chemical poisoning "hypothyroidism"? Untreated hypothyroidism increases morbidity and mortality. [15] [16] There is also the more logical option of support the body's thyroid-hormone producing capabilities using the thyroxine precursor L-tyrosine, a basic amino acid with a relatively high margin of safety. video where the doc is talking about the study , i wlll link study and video below. El almacenamiento o acceso tcnico es estrictamente necesario para el propsito legtimo de permitir el uso de un servicio especfico explcitamente solicitado por el abonado o usuario, o con el nico propsito de llevar a cabo la transmisin de una comunicacin a travs de una red de comunicaciones electrnicas. Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer Posted on: Monday, August 12th 2013 at 7:15 am Written By: Sayer Ji, Founder A new study has. Brit Med J 1978, 1:210212. I am convinced that my lung cancer is related to the thyroid/auto immune issues I've had for years. Given the clear role that selenium deficiency plays in preventing the conversion of T4 to the far more biologically active form of thyroid hormone known as triiodothyronine (T3), which can cause an elevation of thyroxine-stimulating hormone (TSH), why call a mineral deficiency-induced decrease in T4 a monolithic disease entity such as hypothyroidism? PLoSone 2011, 11:e27547. To investigate the magnitude of the possible association between levothyroxine use and cancer risk, this retrospective c A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' florence nightingale concept 2 via de boleto Or, simply look at what the young-adult, T-score based definition of osteoporosis and osteopenia has done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. JavaScript is disabled. ', Study: Millions Treated for Hypothyroidism At Risk for Lung Cancer. [14] In other words, you can 'normalize' the main clinically measurable parameter associated with 'low thyroid function,' i.e. May be of interest: Study: Millions Treated for Hypothyroidism At Risk for, Non-small cell lung cancer - Adenocarcinoma, Non-small cell lung cancer - Squamous cell, Top 5 Questions to Ask Your Lung Cancer Doctor, Patient & Caregiver Network Member Resources, Not A Member Yet? Could be another marmalade how would we know? The reality is that most cases of hypothyroidism today are diagnosed in populations who are experiencing a combination of basic nutritional deficiencies and chemical exposures, or who are simply going through a temporary down-cycle in thyroid function following a natural change, such as the natural postpartum drop that occurs in women after giving birth. [6] Venditti P, Di Stefano L, Di Meo S: Oxidative stress in cold induced hyperthyroid state. They only reappear when I need to fine tune the medication. Post by D.ap Tue Feb 21, 2017 6:40 pm "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and . Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. Content on HealthUnlocked does not replace the relationship between you and doctors or other healthcare professionals nor the advice you receive from them. [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. elevated TSH, without actually improving the overall physiological situation, nor the patients subjective experience of well being. Never delay seeking advice or dialling emergency services because of something that you have read on HealthUnlocked. [4], DI activity in lung cancer was found to be lower than in peripheral lung tissue.[5]. "A new study has uncovered a link between the synthetic thyroid hormone (trade name Synthroid) used to treat millions diagnosed with hypothyroidism and lung cancer, bringing to the forefront the harmful role that overdiagnosis and overtreatment plays in nutritional deficiency and chemical exposure related 'diseases.' According to data from the National Health and Nutrition Examination Survey, years 1988-1994, [13] while 0.3% of the American population exhibits overt symptoms of hypothyroidism, 14 times more (4.3%) have so-called 'subclinical' hypothyroidism only detected via blood work. If the results show that TSH is high and T-4 is low, then the diagnosis . PMID: 11929079, [15] Thanh D Hoang, Cara H Olsen, Vinh Q Mai, Patrick W Clyde, Mohamed K M Shakir. Oops I have just bought my first jar of marmalade in over ten years! Unfortunately, it's quite typical. There is also compelling research indicating that desiccated thyroid extract (Armour thyroid) results in superior clinical outcomes versus the synthetic hormone, especially as concerns improved body weight. I don't think so. The aim of the study was to assess the occurrence and nature of immune-related endocrine adverse events (irAEs) among patients with non-small-cell lung cancer (NSCLC) treated with nivolumab. Yet Another Frankenfood Pandoras Box: the Majorit How Medical Science Proves that Black Is White. In my view the paper isn't worth the pixels used to display it on a screen. In 2020 alone, there were more than 2.2 million new cases and 1.8 million deaths from lung cancer globally. This relatively symptom-free reservoir of 'hypothyroid' cases provides a veritable gold mine of potential office visits, billable services and drug prescriptions. However, the study looked at the incrase of ALL lung cancers, not SCLC, so that data does not correlate with this study. ", Orsomeone posts something about, say a diet or supplement and them some people think they are something it "Cures lung cancer.". Millions of people who were not only wrongly diagnosed with cancers and subsequently aggressively treated for them with chemotherapy, radiation and surgery, are now being told that they would have been better left undiagnosed and untreated. I can understand why tennis 123 wrote, "I have so much to say about this I could write a book". It took over five years before the someone figured out my ongoing symptoms were due to hypothyroidism. One of the main drawbacks of administering T4 in isolation is the possibility that it will not convert adequately to T3, and will therefore 'back up' causing excessive T4 activity, i.e. When a high-risk patient presents with one or more lung nodules, the path ahead and next steps seems obvious. Join the Patient & Caregiver Network. In my opinion, the science of the study doesn't support the conclusion. Or, simply look at what the young-adult,T-score based definition of osteoporosis and osteopeniahas done to convert millions of healthy middle-age and older women into drug-treatable patients, or, what the lipid hypothesis of cardiovascular disease causation has done to create a 30-billion dollar a year market in statin drugs, to fully appreciate the harms of overdiagnosis and overtreatment. This is a horrible disease that ravages the body. I hope that with increased knowledge we will all find the right road. Results indicate that treatment with levothyroxine was linked with significantly increased mortality (hazard ratio = 1.19). [9] [10] [11] Although we should never forget that LT4 is a life-saving thyroid hormone replacement, and that one should not exclude that the pathological reason that leads to the prescription of LT4 could favor the lung cancer development also. They found no significant correlation between T4 sales and breast, colorectal and gastric cancers, but did find a significant correlation for lung cancer (p < 0.05) corrected for smoking and age. Nanosized aluminum being sprayed in the atmosphere CDC Admits as Many as 30 Million Americans Could b Why Turmeric May Be the Diseased Liver's Best Friend. Forgot account? The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. There are several books out there written about the topic. The study looked at the prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 and correlated this data with sales of LT4 in 2009, focusing on women aged 30-84. It does not necessarily imply one thing caused the other. Even acute bouts of stress and subclinical adrenal insufficiency can cause cyclical downshifts in thyroid function. It does not seem to quantify the increased risk, and it keeps saying it is hyperthyroidism that causes the oxidised stress. 500+ pages of Natural Medicine Alternatives and Information. The article also stresses that too many people are being given the diagnosis of either hypo or hyperthyroidism. Researchers are currently studying. Due to excessive bot signups along with nefarious actors we are limiting forum registration.